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・ Actinoporus elegans
・ Actinoposthia beklemischevi
・ Actinoposthiidae
・ Actinoprosopa maris
・ Actinoptera
・ Actinopteri
・ Actinopterygii
・ Actinopteryx
・ Actinoptilum
・ Actinoptilum molle
・ Actinopus
・ Actinopyga
・ Actinoquinol
・ Actinor
・ Actiniidae
Actinin
・ Actinin alpha 4
・ Actinin, alpha 1
・ Actinin, alpha 2
・ Actinioidea
・ Actiniopteris
・ Actiniopteris radiata
・ Actinism
・ Actinistia
・ Actinium
・ Actinium(III) oxide
・ Actino-pnp RNA motif
・ Actinoallomurus
・ Actinoalloteichus
・ Actinobacillosis


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Actinin : ウィキペディア英語版
Actinin
Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinates contractions between sarcomeres in the horizontal axis.
The non-sarcomeric α-actinins, encoded by ACTN1 and ACTN4, are widely expressed. ACTN2 expression is found in both cardiac and skeletal muscle, whereas ACTN2 is limited to the latter. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.
Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis (FSGS).
==See also==

* Actin
* Muscle contraction

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Actinin」の詳細全文を読む



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