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Adamantinoma (from the Greek word ''adamantinos'', meaning "very hard"〔) is a rare bone cancer, making up less than 1% of all bone cancers.〔 It almost always occurs in the bones of the lower leg〔 and involves both epithelial and osteofibrous tissue.〔 The condition was first described by Fischer in 1913.〔〔Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.〕 ==Presentation== Patients typically present with swelling with or without pain. The slow-growing tumor predominantly arises in long bones in a subcortical location (95% in the tibia or fibula).〔 Most commonly, patients are in their second or third decade, but adamantinoma can occur over a wide age range. Benign osteofibrous dysplasia may be a precursor of adamantinoma〔 or a regressive phase of adamantinoma. Histologically, islands of epithelial cells are found in a fibrous stroma. The tumor is typically well-demarcated, osteolytic and eccentric, with cystic zones resembling soap bubbles.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Adamantinoma」の詳細全文を読む スポンサード リンク
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