翻訳と辞書 Words near each other ・ Afdhere Jama ・ Afdlin Shauki ・ AFDX-384 ・ AFE ・ Afe Annang ・ Afe Babalola University ・ Afe Babalola University Faculty of Engineering ・ Afe Babalola University Faculty of Sciences ・ AfE-Turm ・ Afeaki ・ Afeda ・ Afeez Oyetoro ・ Afef Ben Ismail ・ Afef Jnifen ・ Afega ・ Afegostat ・ Afek ・ Afek (mythology) ・ Afek Tounes ・ Afek, Israel ・ Afeka ・ Afeka College of Engineering ・ Afektiven Naboj ・ Afel Bocoum ・ Afelee F. Pita ・ Afeleke Pelenise ・ Afelia ・ Afelimomab ・ Afella ・ Afella Ighir Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Afegostat ： ウィキペディア英語版 Afegostat Afegostat (INN; also known as isofagomine; planned trade name Plicera) was an experimental drug for the treatment of certain forms of Gaucher's disease, that was being developed by Amicus Therapeutics and Shire plc until a failed clinical trial in 2009 led to termination of its development. The substance was used in form of the tartrate. ==Mechanism of action== β-Glucocerebrosidase, an enzyme needed for the metabolisation of glucocerebroside, is misfolded in individuals with Gaucher's disease due to various mutations, one of which is called N370S. Afegostat, an iminosugar, binds selectively to N370S glucocerebrosidase and restores its correct conformation and, consequently, enhances its activity about threefold. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Afegostat」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.