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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Aganirsen ： ウィキペディア英語版 Aganirsen Aganirsen (previously GS-101) is a 25 mer DNA antisense oligonucleotide therapeutic inhibiting insulin receptor substrate-1 (IRS-1), which is being investigated as a topical treatment for ocular neovascularisation. Aganirsen is a candidate for the treatment of ocular neovascularization in patients suffering from front of the eye (cornea) or back of the eye (retinal) diseases, including progressive corneal neovascularisation in patients suffering from infectious keratitis and wet age related macular degeneration (AMD). Aganirsen actively inhibits the production of IRS-1 by binding IRS-1 mRNA (antisense therapy). Aganirsen therefore induces an upstream inhibition of the neovascularization pathway, most notably by inhibiting excess VEGF and Il-1β expression. ==Structure== Aganirsen is a 25-mer (5’-TATCCGGAGGGCTCGCCATGCTGCT-3’), first-generation antisense oligonucleotide (phosphorothioate linkage). Aganirsen has a molecular mass of 8036 (Da), a melting point of approximately 64.2 °C, and a GC content of 64%. Aganirsen is highly soluble in water. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Aganirsen」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.