翻訳と辞書 Words near each other ・ Agelaea fulva ・ Agelaea himalayica ・ Agelaia ・ Agelaia multipicta ・ Agelaia pallipes ・ Agelaia vicina ・ Agelaius ・ Agelanthus ・ Agelas ・ Agelas clathrodes ・ Agelas conifera ・ Agelas flabelliformis ・ Agelas gracilis ・ Agelas schmidti ・ Agelasimine ・ Agelasine ・ Agelasta ・ Agelasta (genus) ・ Agelastes ・ Agelastica alni ・ Agelasticus ・ Agelaus ・ Agelaus of Naupactus ・ Ageleia ・ Agelena ・ Agelena atlantea ・ Agelena australis ・ Agelena babai ・ Agelena bifida ・ Agelena borbonica Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Agelasine ： ウィキペディア英語版 Agelasine Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (''Agelas'' sp.). They are considered secondary metabolites. Their contribution to the sponge is assumed to be some sort of protection against microorganisms. At the present time a total of eleven 9-methyladeninium salts, agelasine A–I, epiagelasine C and agelin B, are known.〔H. Nakamura, H. Wu, Y. Ohizumi and Y. Hirata, Tetrahedron Lett., 1984, 25, 2989〕〔H. Wu, H. Nakamura, J. Kobayashi and Y. Ohizumi, Tetrahedron Lett., 1984, 25, 3719〕〔R. J. Capon and D. J. Faulkner, J. Am. Chem. Soc., 1984, 106, 1819〕〔H. Wu, H. Nakamura, J. Kobayashi, M. Kobayashi, Y. Ohizumi and Y. Hirata, Bull. Chem. Soc. Jpn., 1986, 59, 2495〕〔K. Ishida, M. Ishibashi, H. Shigemori, T. Sasaki and J. Kobayashi, Chem. Pharm. Bull., 1992, 40, 766〕〔T. Hattori, K. Adachi and Y. Shizuri, J. Nat. Prod., 1997, 60, 411〕〔X. Fu, F. J. Schmitz, R. S. Tanner and M. Kelly-Borges, J. Nat. Prod., 1998, 61, 548〕 All compounds carry a diterpenoid side chain in the adenine 7-position. The agelasines are closely related in structure with the agelasimines. Chemists have reproduced (–)-agelasine A,〔E. Piers, M. L. Livain, Y. Han, G. L. Plourde, L. Guy and W.-L. Yeh, J. Chem. Soc., Perkin Trans. 1, 1995, 963〕 (–)-agelasine B,〔E. Piers and J. Y. Roberge, Tetrahedron Lett., 1992, 33, 6923; (b) H. Iio, K. Asao and T. Tokoroyama, J. Chem. Soc., Chem. Commun., 1985, 774〕 (−)-agelasine E,〔A. K. Bakkestuen, L.-L. Gundersen, D. Petersen, B. Utenova and A. Vik, Org. Biomol. Chem., 2005, 3, 1025〕 (−)-agelasine F,〔K. Asao, H. Iio and T. Tokoroyama, Tetrahedron Lett., 1989, 30, 6401〕 and (+)-agelasine D〔B. T. Utenova and L.-L. Gundersen, Tetrahedron Lett., 2004, 45, 4233〕 by organic synthesis. Agelasines are associated with bioactivities such as antimicrobial and cytotoxic effects, as well as contractive responses of smooth muscles and inhibition of Na/K-ATPase (NaKATPase). Furthermore, in vitro activity against Mycobacterium tuberculosis is reported for agelasine F.〔G. C. Mangalindan, M. T. Talaue, L. J. Cruz, S. G. Franzblau, L. B. Adams, A. D. Richardson, C. M. Ireland and G. P. Conception, Planta Med., 2000, 66, 364〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Agelasine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.