翻訳と辞書
Words near each other
・ Aldona Jonaitis
・ Aldona Jonuškaitė-Šaltenienė
・ Aldona Klimavičiūtė
・ Aldona Ličkutė-Jusionienė
・ Aldona Margenytė
・ Aldona Młyńczak
・ Aldona Nenėnienė
・ Aldona of Lithuania
・ Aldona Orman
・ Aldona Wos
・ Aldona Čiukšytė
・ Aldonata
・ Aldonic acid
・ Aldons Vrubļevskis
・ Aldonza
Aldophosphamide
・ Aldor
・ Aldor Ingebrigtsen
・ Aldora, Georgia
・ Aldorough
・ Aldos-2-ulose dehydratase
・ Aldose
・ Aldose 1-dehydrogenase
・ Aldose 1-epimerase
・ Aldose beta-D-fructosyltransferase
・ Aldose reductase
・ Aldose reductase inhibitor
・ Aldose-1-phosphate adenylyltransferase
・ Aldose-1-phosphate nucleotidyltransferase
・ Aldose-6-phosphate reductase (NADPH)


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

Aldophosphamide : ウィキペディア英語版
Aldophosphamide

Aldophosphamide is a tautomer of the main active metabolite of the alkylating antineoplastic agent cyclophosphamide - the 4-hydroxycyclophosphamide. Some of the aldophosphamide is then intracellularly hydrolyzed by the enzyme phosphatase to the of the two directly cytotoxically active metabolites - phosphoramide mustard and acrolein - in the metabolic activation pathway of the cyclophosphamide. But most of the aldophosphamide undergoes metabolic inactivation, catalyzed by another enzyme, ALDH, which gives rise to carboxycyclophosphamide.
Aldophosphamide residue is a component in molecules of some new oxazaphosphorine anticancer drugs that are now underway in clinical and preclinical testing: the NSC 612567 (aldophosphamide perhydrothiazine) and NSC 613060 (aldophosphamide thiazolidine).〔(Design of new oxazaphosphorine anticancer drugs )〕
== References ==




抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Aldophosphamide」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.