翻訳と辞書 Words near each other ・ Alibori Department ・ Alibori River ・ Aliboron ・ Aliboron antennatum ・ Aliboron bukidnoni ・ Aliboron granulatum ・ Aliboron laosense ・ Aliboron wongi ・ Alibre Design ・ Alibris ・ Alibunar ・ Alibánfa ・ Alibée Féry ・ Alic Halford Smith ・ Alica Javadová ・ Alicaforsen ・ Alican (disambiguation) ・ Alican Güney ・ Alican Karataş ・ Alican Kaynar ・ Alicante ・ Alicante (disambiguation) ・ Alicante (DO) ・ Alicante (mythology) ・ Alicante (Spanish Congress Electoral District) ・ Alicante (tomato) ・ Alicante 8 ・ Alicante Bouschet ・ Alicante CF ・ Alicante CF B Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Alicaforsen ： ウィキペディア英語版 Alicaforsen Alicaforsen is an inflammatory bowel disease drug candidate. It is an antisense therapeutic that targets the messenger RNA for the production of human ICAM-1 protein. It is being progressed through clinical development as a nightly enema. == Structure and mode of action == Alicaforsen is a 20 unit phosphorothiate modified antisense oligonucleotide. It is designed to specifically inhibit and down-regulate at a cell level the production of human ICAM-1 protein. ICAMs are proteins that induce inflammatory responses in tissues in the body, including the gastro-intestinal tract. ICAM-1 propagates an inflammatory response, promoting the extravasation and activation of leukocytes (white blood cells) into inflamed tissue.〔 Alicaforsen works by binding to the section of messenger RNA that encodes for ICAM-1, and also by degrading ICAM-1 (through an RNase-H based mechanism).〔 This causes a reduction in both ICAM-1 expression on cell surfaces and a selective reduction in ICAM-1 mRNA. In particular, it down-regulates ICAM-1 on vascular endothelial cells, inhibiting leucocyte adherence, migration and activation. In effect, alicaforsen is switching off the inflammatory process enabling tissue healing. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Alicaforsen」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.