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Allele
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・ Allele-specific oligonucleotide
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・ Allelomimetic behavior
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・ Alleluia (Thompson)


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Allele : ウィキペディア英語版
Allele

An allele ( or ), or allel, is one of a number of alternative forms of the same gene or same genetic locus.〔〔 Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation. However, most genetic variations result in little or no observable variation.
Most multicellular organisms have two sets of chromosomes; that is, they are diploid. These chromosomes are referred to as homologous chromosomes. Diploid organisms have one copy of each gene (and, therefore, one allele) on each chromosome. If both alleles are the same, they and the organism are homozygous with respect to that gene. If the alleles are different, they and the organism are heterozygous with respect to that gene.
The word "allele" is a short form of allelomorph ("other form"), which was used in the early days of genetics to describe variant forms of a gene detected as different phenotypes. It derives from the Greek prefix ''ἀλλήλ'', ''allel'', meaning "reciprocal" or "each other", which itself is related to the Greek adjective ἄλλος (allos; cognate with Latin "alius"), meaning "other".
==Dominant and recessive alleles==
(詳細はdominant or recessive, according to which of the two homozygous phenotypes the heterozygote most resembles. Where the heterozygote is indistinguishable from one of the homozygotes, the allele involved is said to be dominant to the other, which is said to be recessive to the former.〔 The degree and pattern of dominance varies among loci. This type of interaction was first formally described by Gregor Mendel. However, many traits defy this simple categorization and the phenotypes are modeled by co-dominance and polygenic inheritance.
The term "wild type" allele is sometimes used to describe an allele that is thought to contribute to the typical phenotypic character as seen in "wild" populations of organisms, such as fruit flies (''Drosophila melanogaster''). Such a "wild type" allele was historically regarded as dominant, common, and normal, in contrast to "mutant" alleles regarded as recessive, rare, and frequently deleterious. It was formerly thought that most individuals were homozygous for the "wild type" allele at most gene loci, and that any alternative "mutant" allele was found in homozygous form in a small minority of "affected" individuals, often as genetic diseases, and more frequently in heterozygous form in "carriers" for the mutant allele. It is now appreciated that most or all gene loci are highly polymorphic, with multiple alleles, whose frequencies vary from population to population, and that a great deal of genetic variation is hidden in the form of alleles that do not produce obvious phenotypic differences.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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