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Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA Gyrase enzyme involved in the cell division in bacteria. They are derived from '' Streptomyces '' species, whose best-known representative - '' Streptomyces coelicolor'' - was completely sequenced in 2002.〔Bentley SD, ''et al.''. Complete genome sequence of the model actinomycete "Streptomyces coelicolor" A3(2). ''Nature''. 2002 (417)141–147 http://www.nature.com/nature/journal/v417/n6885/abs/417141a.html〕 The Aminocoumarin antibiotics include: * Novobiocin, Albamycin (Pharmacia And Upjohn) * Coumermycin * Clorobiocin ==Structure== The core of aminocoumarin antibiotics is made up of a 3-Amino-4,7-dihydroxycumarin ring, which is linked, e.g., with a sugar in 7-Position and a benzoic acid derivative in 3-Position. Clorobiocin is a natural antibiotic isolated from several ''Streptomyces'' strains and differs from novobiocin in that the methyl group at the 8 position in the coumarin ring of novobiocin is replaced by a chlorine atom, and the carbamoyl at the 3' position of the noviose sugar is substituted by a 5-methyl-2-pyrrolylcarbonyl group.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Aminocoumarin」の詳細全文を読む スポンサード リンク
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