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・ Aminobutyrate aminotransferase
・ Aminobutyric acid
・ Aminocandin
・ Aminocaproic acid
・ Aminocarb
・ Aminocarboxymuconate-semialdehyde decarboxylase
・ Aminocoumarin
・ Aminocyclitol
・ Aminocyclopropanecarboxylate oxidase
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・ Aminodeoxychorismate lyase
・ Aminodeoxychorismate synthase
・ Aminoethylethanolamine
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Aminoglutethimide
・ Aminoglycoside
・ Aminoglycoside N3'-acetyltransferase
・ Aminoglycoside N6'-acetyltransferase
・ Aminoglycoside-3'-phosphotransferase
・ Aminohippuric acid
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・ Aminoimidazolase
・ Aminoisobutyric acid
・ Aminoketone
・ Aminolevulinate transaminase
・ Aminolevulinic acid
・ Aminolevulinic acid dehydratase deficiency porphyria
・ Aminolevulinic acid synthase
・ Aminolysis


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Aminoglutethimide : ウィキペディア英語版
Aminoglutethimide

Aminoglutethimide is an anti-steroid drug marketed under the tradename Cytadren by Novartis around the world. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also used by body builders.
==Mechanism==
Aminoglutethimide has two mechanisms of action:
# It blocks aromatase in the generation of estrogens from androstenedione and testosterone.
# It blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme P450scc and consequently decreases synthesis of all hormonally active steroids.
At low doses, aminogluthethimide is only an effective inhibitor of aromatase, but at higher doses, it effectively blocks P450scc as well.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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