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Amorphosynthesis : ウィキペディア英語版 | Amorphosynthesis Amorphosynthesis is a medical condition where the patient is unaware of somatic sensations from one side of the body; the left side is most commonly affected. This condition is usually a sign of a lesion in the right parietal lobe. The patient also shows loss of proprioception and spatial relationships. Additionally, when the somatosensory association area is damaged one loses the ability to recognize a complex object on the opposite side of the body. ==Description== Amorphosynthesis, also called a hemi-sensory deficit, is a neuropsychological condition in which a patient experiences unilateral inattention to sensory input.〔Unsworth, C. A. (). Cognitive and Perceptual Dysfunction. Philadelphia: Davis Company.〕 This phenomenon is frequently associated with damage to the right cerebral hemisphere resulting in severe sensory deficits that are observed on the contralesional (left) side of the body. A right-sided deficit is less commonly observed and the effects are reported to be temporary and minor.〔Weintraub, S., Ahern, G. L., Daffner, K.R. & Price, B.H. (). Right-sided hemispatial neglect. Neurology, 42(): 223.〕 Evidence suggests that the right cerebral hemisphere has a dominant role in attention and awareness to somatic sensations through ipsilateral and contralateral stimulation.〔Mesulam, M-M. (). A cortical network for directed attention and unilateral neglect. Ann Neurol, 10: 309-325.〕〔Mesulam, M-M. (). Large-scale neurocognitive networks and distributed processing for attention, language and memory. Ann Neurol, 28: 597-613.〕〔Heinman, K. M. & Valenstein, E. (). Neglect and related disorders. New York: Oxford University Press.〕 In contrast, the left cerebral hemisphere is activated only by contralateral stimuli.〔Heinman, K. M. & Van Den Abell, T. (). Right hemispheric dominance for attention: the mechanism underlying hemispheric asymmetries of inattention. Neurology, 30: 327-330.〕〔Gitelman, D. R., Alpert, N., Kosslyn, S., Daffner, K., Scinto, L., Thompson, W. & Mesulam, M-M. (). Functional imaging of exploratory attentional movements. Neurology, 44: 328.〕〔Reivich, M., Gur, R. & Alavi, A. (). Positron emission tomographic studies of sensory stimuli, cognitive processes and anxiety. Hum Neurobiol, 2: 25-33.〕 Thus, the left and right cerebral hemispheres exhibit redundant processing to the right-side of the body and a lesion to the left cerebral hemisphere can be compensated by the ipsiversive processes of the right cerebral hemisphere.〔Iachini, T., Ruggiero, G., Conson, M. & Trojano, L. (). Lateralization of egocentric and allocentric spatial processing after parietal brain lesions. Brain and Cognition, 69(): 512-520.〕 For this reason, right-sided amorphosynthesis is less often observed and is generally associated with bilateral lesions.〔Weintraub, S., Daffner, K. R, Ahern, G. L., Price, B. H., & Mesulam, M-M. (). Right-sided hemispatial neglect and bilateral cerebral lesions. J Neurol Neurosurg Psychiatry, 60: 342-344.〕
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