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Amperozide
Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor.〔Svartengren J, Simonsson P. Receptor binding properties of amperozide. ''Pharmacology and Toxicology''. 1990;66 Suppl 1:8-11. PMID 2154737〕 It does not block dopamine receptors as with most antipsychotic drugs,〔Meltzer HY, Zhang Y, Stockmeier CA. Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: implications for antipsychotic action. ''European Journal of Pharmacology''. 1992 May 27;216(1):67-71. PMID 1388121〕 but does inhibit dopamine release,〔Eriksson E. Amperozide, a putative anti-psychotic drug: uptake inhibition and release of dopamine in vitro in the rat brain. ''Life Sciences''. 1990;47(23):2111-7. PMID 1979998〕〔Yamamoto BK, Meltzer HY. The effect of the atypical antipsychotic drug, amperozide, on carrier-mediated striatal dopamine release measured in vivo. ''Journal of Pharmacology and Experimental Therapeutics''. 1992 Oct;263(1):180-5. PMID 1403783〕 and alters the firing pattern of dopaminergic neurons.〔Grenhoff J, Tung CS, Ugedo L, Svensson TH. Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo. ''Pharmacology and Toxicology''. 1990;66 Suppl 1:29-33. PMID 2304893〕 It was investigated for the treatment of schizophrenia in humans,〔Axelsson R, Nilsson A, Christensson E, Björk A. Effects of amperozide in schizophrenia. An open study of a potent 5-HT2 receptor antagonist. ''Psychopharmacology (Berlin)''. 1991;104(3):287-92. PMID 1924636〕 but never adopted clinically, its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.〔Kyriakis SC, Martinsson K, Olsson NG, Bjork A. Thin sow syndrome (TSS): the effect of amperozide. ''British Veterinary Journal''. 1990 Sep-Oct;146(5):463-7. PMID 2224491〕〔Kyriakis SC, Olsson NG, Martinsson K, Björk AK. Observations on the action of amperozide: are there social influences on sow-litter productivity? ''Research in Veterinary Science''. 1991 Sep;51(2):169-73. PMID 1788479〕〔Papp I, Waller C, Biro O. Practical experiences in the therapy of postweaning edema disease in piglets. ''Berliner und Munchener Tierarztliche Wochenschrift''. (German) 1996 Oct;109(10):385-7. PMID 8999770〕
==See also==
*Penfluridol (Semap, Micefal, "Longoperidol")
*Pimozide
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