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Amphetaminil
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Amphetaminil : ウィキペディア英語版
Amphetaminil

Amphetaminil (Aponeuron, AN-1) is a stimulant drug derived from amphetamine, which was developed in the 1970s and used for the treatment of obesity,〔Harris LS. The stimulants and hallucinogens under consideration: a brief overview of their chemistry and pharmacology. ''Drug and Alcohol Dependence'' 1986; 17:107.〕 ADHD,〔Meyer-Probst B, Vehreschild T. Influencing the lack of concentration in hyperkinetic schoolchildren with Aponeuron. ''Psychiatrie, Neurologie und Medizinische Psychologie (Leipz)'' 1976; 28:491.〕〔Paclt I, Florian J, Brunclikova J, Ruzickova I. Effect of Aponeuron in the treatment of children with hyperkinetic syndrome. (Czech). ''Ceska a Slovenska Psychiatrie''. 1996 May;92 Suppl 1:41-57.〕 and narcolepsy.〔Schlesser JL. Drugs Available Abroad - A Guide to Therapeutic Drugs Approved Outside the US. MEDEX Books, Detroit, 1991.〕 It has largely been withdrawn from clinical use following problems with abuse.〔Winter E. Drug abuse and dependence of the amphetamine type with special regard to Amphetaminil (Aponeuron(R)). (German). ''Psychiatrie, Neurologie und Medizinische Psychologie (Leipzig)''. 1976 Sep;28(9):513-25.〕
== Stereochemistry ==
Amphetaminil is a molecule with two stereogenic centers. Thus, four different stereoisomers exist:
420px
* (''R'')-2-()-2-phenylacetonitrile (CAS-Nr. 478392-08-4)
* (''S'')-2-()-2-phenylacetonitrile (CAS-Nr. 478392-12-0)
* (''R'')-2-()-2-phenylacetonitrile (CAS-Nr. 478392-10-4)
* (''S'')-2-()-2-phenylacetonitrile (CAS-Nr. 478392-14-2)

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