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Anamorelin
Anamorelin (INN) (developmental code names ONO-7643, RC-1291, ST-1291), also known as anamorelin hydrochloride (USAN, JAN), is a non-peptidic, orally-active, centrally-penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) with appetite-enhancing and anabolic effects which is under development by Helsinn Therapeutics for the treatment of cancer cachexia and anorexia.
Anamorelin significantly increases plasma levels of growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor-binding protein 3 (IGFBP-3) in humans, without affecting plasma levels of prolactin, cortisol, insulin, glucose, adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyroid-stimulating hormone (TSH).〔 In addition, anamorelin significantly increases appetite, overall body weight, lean body mass, and muscle strength,〔〔 with increases in body weight correlating directly with increases in plasma IGF-1 levels.〔
As of June 2015, anamorelin is in several phase III clinical trials for the treatment of cancer cachexia and anorexia associated with non-small-cell lung carcinoma.
==See also==
* Capromorelin
* Examorelin (hexarelin)
* GHRP-6 (SKF-110679)
* Ibutamoren (MK-677)
* Ipamorelin
* Macimorelin
* Pralmorelin (GHRP-2)
* Relamorelin
* SM-130,686
* Tabimorelin
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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