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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Andarine ： ウィキペディア英語版 Andarine Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,〔Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, Marhefka CA, Veverka KA, Miller DD, Dalton JT. Pharmacodynamics of selective androgen receptor modulators. ''Journal of Pharmacology and Experimental Therapeutics''. 2003 Mar;304(3):1334-40. PMID 12604714〕 using the non-steroidal androgen antagonist bicalutamide as a lead compound.〔Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. ''Molecular Interventions''. 2005 Jun;5(3):173-88. PMID 15994457〕 Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.〔Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. ''Endocrinology''. 2004 Dec;145(12):5420-8. PMID 15308613〕 This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.〔Gao W, Kim J, Dalton JT. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. ''Pharmaceutical Research''. 2006 Aug;23(8):1641-58. PMID 16841196〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Andarine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.