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Anticalins are artificial proteins that are able to bind to antigens, either to proteins or to small molecules. They are not structurally related to antibodies, which makes them a type of antibody mimetic. Instead, they are derived from human lipocalins which are a family of naturally binding proteins. Anticalins are being used in lieu of monoclonal antibodies, but are about eight times smaller with a size of about 180 amino acids and a mass of about 20 kDa. The Anticalin technology is exclusively commercialized by Pieris Pharmaceuticals in Freising, Germany.〔(【引用サイトリンク】url=http://www.pieris.com/ )〕 ==Properties== Anticalins have better tissue penetration than antibodies and are stable at temperatures up to 70 °C. Unlike antibodies, they can be produced in bacterial cells like ''E. coli'' in large amounts.〔 While antibodies can only be directed at macromolecules such as proteins and at small molecules (haptens) only if bound to macromolecules,〔 anticalins are able to selectively bind to small molecules as well. They were mainly developed at the University of Technology Munich and are currently used as research tools. Diagnostic and therapeutic applications, including the use for targeted drug delivery, are being aimed at.〔 The underlying technology was nominated for the German Future Prize in 2004.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Anticalin」の詳細全文を読む スポンサード リンク
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