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Aptazapine : ウィキペディア英語版
Aptazapine

Aptazapine (CGS-7525A) is a tetracyclic antidepressant (TeCA) which was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine.〔 Based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
== See also ==

* Mianserin
* Mirtazapine
* Setiptiline

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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