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|Section2= |Section3= }} Arenobufagin is a cardiotoxic bufanolide steroid secreted by the Argentine toad ''Bufo arenarum''.〔Garraffo HM, Gros EG. Biosynthesis of bufadienolides in toads. VI. Experiments with ()cholesterol, ()coprostanol, and 5 beta-()pregnanolone in the toad Bufo arenarum. ''Steroids''. 1986 Sep-Oct;48(3-4):251-7. PMID 3127947〕 It has effects similar to digitalis, blocking the Na+/K+ pump in heart tissue.〔Cruz J dos S, Matsuda H. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. ''European Journal of Pharmacology''. 1993 Aug 3;239(1-3):223-6. PMID 8223897〕 ==Sources== The compound Arenobufagin is one of the major components of toad venom( (Venenum bufonis) . It is derived from the dried skin of giant toads, such as the Bufo gargarizans or the Bufo melanostictus Suhneider. Arenobufagin is specifically secreted by the Rhinella arenarum, which is found in South American nature. The venom of these toad species contains about 1,75% of arenobufagin.〔Li M, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu J, Zhang D, Tian H, Li Y, Ye W. (2012). “Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGFmediated angiogenesis through suppression of VEGFR-2 signaling pathway.” Biochemical Pharmacology. 83, 1251–1260〕 The other, major, part of the venom consists mostly of similar looking bufagins, which are all toxic steroides. Toads produce their venom when they are scared, injured or provoked, as a defence mechanism against their predators 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Arenobufagin」の詳細全文を読む スポンサード リンク
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