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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Arfendazam ： ウィキペディア英語版 Arfendazam Arfendazam is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam. Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.〔Müller E. Benzodiazepine receptor interactions of arfendazam, a novel 1, 5-benzodiazepine. ''Pharmacopsychiatry'' 1985, (18):10-11.〕〔Müller WE, Groh B, Bub O. In vitro and in vivo studies of the mechanism of action of arfendazam, a novel 1, 5-benzodiazepine. ''Pharmacopsychiatry'' 1986, (10):314-315.〕 Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.〔J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. ''The Pharmacology of Sleep''. Springer. ISBN 978-3-540-58961-7〕 ==See also== *Benzodiazepine 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Arfendazam」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.