翻訳と辞書 Words near each other ・ Arkendale, Virginia ・ Arkengarthdale ・ Arkengarthdale Gunnerside and Reeth Moors ・ Arkens, Franeker ・ Arkenu structures ・ Arkeology ・ Arkeology (The Ark album) ・ Arkeology (World Party album) ・ Arkeon ・ Arkera ・ Arkesden ・ Arkesh Singh Deo ・ Arkesilas Cup ・ Arkesilas Painter ・ Arkesta ・ Arketamine ・ Arkforce ・ Arkh ・ Arkh-e Bozorg ・ Arkh-e Kuchek ・ Arkha ・ Arkha, Raebareli ・ Arkhale ・ Arkhale, Lumbini ・ Arkhale, Sagarmatha ・ Arkhalig ・ Arkham ・ Arkham (disambiguation) ・ Arkham Asylum ・ Arkham Asylum – Shock Therapy Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Arketamine ： ウィキペディア英語版 Arketamine Arketamine, also (''R'')-ketamine or ''R''(–)-ketamine, is the (''R'')-(–) enantiomer of ketamine. Unlike racemic ketamine and esketamine, the ''S''(+) enantiomer of ketamine, arketamine is less potent pharmacologically and has never been approved or marketed as an enantiopure drug for clinical use, though it is still active.〔 Relative to esketamine, arketamine possesses 4–5 times lower affinity for the PCP site of the NMDA receptor.〔〔 In accordance, arketamine is significantly less potent than racemic ketamine and especially esketamine in terms of anesthetic, analgesic, and sedative-hypnotic effects.〔〔 Racemic ketamine has weak affinity for the sigma receptor, where it acts as an agonist, whereas esketamine binds negligibly to this receptor, and so the sigma receptor activity of racemic ketamine lies in arketamine. It has been suggested that this action of arketamine may play a role in the hallucinogenic effects of racemic ketamine and that it may be responsible for the lowering of the seizure threshold seen with racemic ketamine.〔〔 Esketamine inhibits the dopamine transporter about 8-fold more potently than does arketamine, and so is about 8 times more potent as a dopamine reuptake inhibitor. Arketamine and esketamine possess similar potency for interaction with the muscarinic acetylcholine receptors. Paradoxically, arketamine shows greater and longer-lasting rapid antidepressant effects in animal models of depression relative to esketamine. It has been suggested that this difference may have due to with the possibility of different activity of arketamine and esketamine and their respective metabolites at the α7-nicotinic receptor, as norketamine and hydroxynorketamine are potent antagonists of this receptor and markers of potential rapid antidepressant effects (specifically, increased mammalian target of rapamycin function) correlate closely with their affinity for it. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Arketamine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.