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Arterolane
Arterolane, also known as OZ277 or RBx 11160, is a substance being tested for antimalarial activity by Ranbaxy Laboratories.〔(Blow to Ranbaxy drug research plans ) at LiveMint.com, Sep 21 2007〕 It was discovered by US and European scientists who were coordinated by the Medicines for Malaria Venture (MMV). Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide (trioxolane) group and an adamantane substituent.〔(''In the Pipeline'': "Ozonides As Drugs: What Will They Think Of Next?" ), by Derek Lowe; published November 23, 2009; retrieved November 17, 2015; at Sciencemag.org〕 Phase III clinical trials of arterolane, in combination with piperaquine, began in India in 2009.〔(Indian company starts Phase III trials of synthetic artemisinin ), May 4 2009, at the WorldWide Antimalarial Resistance Network〕 When clinical trial results were disappointing, the MMV withdrew support〔 and Ranbaxy continued developing the drug combination on its own. ==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Arterolane」の詳細全文を読む
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