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Atracurium besylate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. == Intramuscular function parameters == *ED95: the dose of any given intramuscular-blocking agent required to produce 95% suppression of muscle twitch (e.g., the ''abductor'' ''pollicis'') response with balanced anesthesia *Clinical duration: difference in time between time of injection and time to 25% recovery from neuromuscular block *Train-of-Four (TOF) response: stimulated muscle twitch response in trains of four when stimuli are applied in a burst of four as opposed to a single stimulus, equal depression in depolarizing and fading response with non-depolarizing blocker. *25%-75% recovery index: an indicator of the ''rate'' of skeletal muscle recovery - essentially, the difference in time between the time to recovery to 25% and time to recovery to 75% of baseline value *T4:T1 ≥ 0.7: a 70% ratio of the fourth twitch to the first twitch in a TOF - provides a measure of the recovery of neuromuscular function *T4:T1 ≥ 0.9: a 90% ratio of the fourth twitch to the first twitch in a TOF - provides a measure of the full recovery of neuromuscular function 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Atracurium besilate」の詳細全文を読む スポンサード リンク
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