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Avanafil
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2012 and by EMA on June 21, 2013.〔(【引用サイトリンク】 Spedra (avanafil) )〕 Avanafil is known by the trademark names Stendra and Spedra and was developed by Vivus Inc. In July 2013 Vivus announced partnership with Menarini Group, which will commercialise and promote Spedra in over 40 European countries plus Australia and New Zealand.〔http://ir.vivus.com/releasedetail.cfm?releaseid=775706〕 Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.〔(【引用サイトリンク】 publisher = Medicine Net )〕 Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors.〔(【引用サイトリンク】publisher = HealthExpress )〕 It is absorbed quickly, reaching a maximum concentration in about 30–45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutes.〔
==Synthesis==
Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative:〔Yamada, K.; Matsuki, K.; Omori, K.; Kikkawa, K.; 2004, 〕
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抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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