翻訳と辞書 Words near each other ・ Azeem Hafeez ・ Azeem Pitcher ・ Azeem Pura ・ Azeem Rafiq ・ Azeemiyya ・ Azeez Issa Adesiji ・ Azeez Kayode Fakeye ・ Azaruddin Bloch ・ Azarug ・ Azaruja sausage ・ Azary Abramovich Lapidus ・ Azarya ben Ephraim Figo ・ Azarías Pallais ・ Azas ・ Azas (disambiguation) ・ Azaserine ・ Azasetron ・ Azaspiracid ・ Azaspirodecane ・ Azaspirodecanedione ・ Azastene ・ Azat ・ Azat (disambiguation) ・ Azat Abbasov ・ Azat Artsakh ・ Azat Bairyyev ・ Azat Karachurin ・ Azat Mashurov ・ Azat Muhadow ・ Azat Nurgaliev Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Azaserine ： ウィキペディア英語版 Azaserine Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine. Azazerine acts by competitively inhibiting glutamine amidotransferase, a key enzyme responsible for glutamine metabolism. == Mechanism of Action == Azaserine inhibits the rate limiting step of the metabolic hexosamine pathway and an irreversibly inhibits γ-glutamyltransferase by acting directly at the substrate-binding pocket. Independent of hexosamine pathway inhibition, azaserine has been demonstrated to protect against hyperglycemic endothelial damage by elevating serum concentrations of manganese-superoxide dismutase, directly reducing the concentration of reactive oxygen species. Azaserine also downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α, and research indicates that it may have potential in identifying the L-leucine-favoring system transporter in human T-lymphocytes. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Azaserine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.