翻訳と辞書 Words near each other ・ BCKDHB ・ BCKDK ・ BCL ・ BCL Molecular ・ BCL Springs ・ Bcl-2 ・ Bcl-2 family ・ Bcl-2 homologous antagonist killer ・ Bcl-2-associated death promoter ・ Bcl-2-associated X protein ・ Bcl-2-interacting killer ・ BCL-6 corepressor ・ Bcl-x interacting domain ・ Bcl-xL ・ BCL10 ・ BCL11A ・ BCL11B ・ BCL2-like 1 (gene) ・ BCL2-related protein A1 ・ BCL2L10 ・ BCL2L11 ・ BCL2L12 ・ BCL2L13 ・ BCL2L14 ・ BCL2L2 ・ BCL3 ・ BCL6 ・ BCL6B ・ BCL9 ・ BCLAF1 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク BCL11A ： ウィキペディア英語版 BCL11A B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the ''BCL11A'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53335 )〕 == Function == This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Five alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.〔 In addition to the functions described above, BCL11A has been found to play a role in the suppression of fetal hemoglobin production. Therapeutic strategies aimed at increasing fetal globin production in diseases such as beta thalassemia and sickle cell anemia by inhibiting BCL11A are currently being explored. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「BCL11A」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.