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Words near each other
・ Bcl-2
・ Bcl-2 family
・ Bcl-2 homologous antagonist killer
・ Bcl-2-associated death promoter
・ Bcl-2-associated X protein
・ Bcl-2-interacting killer
・ BCL-6 corepressor
・ Bcl-x interacting domain
・ Bcl-xL
・ BCL10
・ BCL11A
・ BCL11B
・ BCL2-like 1 (gene)
・ BCL2-related protein A1
・ BCL2L10
BCL2L11
・ BCL2L12
・ BCL2L13
・ BCL2L14
・ BCL2L2
・ BCL3
・ BCL6
・ BCL6B
・ BCL9
・ BCLAF1
・ BCLUW Community School District
・ BCM
・ BCM Classification
・ BCM Gravelines
・ BCM theory


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BCL2L11 : ウィキペディア英語版
BCL2L11

Bcl-2-like protein 11 is a protein that in humans is encoded by the ''BCL2L11'' gene.
== Function ==

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10018 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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