翻訳と辞書 Words near each other ・ BCL-6 corepressor ・ Bcl-x interacting domain ・ Bcl-xL ・ BCL10 ・ BCL11A ・ BCL11B ・ BCL2-like 1 (gene) ・ BCL2-related protein A1 ・ BCL2L10 ・ BCL2L11 ・ BCL2L12 ・ BCL2L13 ・ BCL2L14 ・ BCL2L2 ・ BCL3 ・ BCL6 ・ BCL6B ・ BCL9 ・ BCLAF1 ・ BCLUW Community School District ・ BCM ・ BCM Classification ・ BCM Gravelines ・ BCM theory ・ BCMA ・ BCMaterials ・ BCMP ・ BCMP network ・ BCMS ・ BCMS UAV Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク BCL6 ： ウィキペディア英語版 BCL6 B-cell lymphoma 6 protein is a protein that in humans is encoded by the ''BCL6'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=604 )〕 Like BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. == Function == The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL), and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain. Physiologically, BCL6 is a master transcription factor which leads the differentiation of naive helper T cells in Follicular Helper T cells (TFH cells). Its action is negatively regulated by the gene PRDM1 encoding the transcription factor Blimp-1. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「BCL6」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.