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BD1063 or 1-()-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of ''K''i = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.〔 In other animal studies, BD1063 blocks the effects of MDMA, and reduces alcohol intake in rodent models of alcoholism. ==See also== * BD1008 * BD1031 * LR132 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「BD1063」の詳細全文を読む スポンサード リンク
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