| 翻訳と辞書 |
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene also known as Bmal, Mop3, TIC, JAP3, PASD3, Bmal1c, bHLHe5.
ARNTL encodes for a transcription factor with a basic helix-loop-helix (bHLH) and a PAS domain. The human ''ARNTL'' gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome.〔(【引用サイトリンク】Homo sapiens (human) ) "> website=National Center for Biotechnology Information )〕 The ''BMAL1'' protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian autoregulatory transcription translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns.〔(【引用サイトリンク】 url = http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARNTL )〕 BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.
== History ==
The Arntl gene was originally discovered in 1997 by two groups of researchers, John B. Hogenesch et al. in March and Ikeda and Nomura in April as part of a superfamily of PAS domain transcription factors.〔 The ARNTL protein, also known as MOP3, was found to dimerize with MOP4, CLOCK, and hypoxia-inducible factors. The names BMAL1 and ARNTL were adopted in later papers. One of ARNTL protein's earliest discovered functions in circadian regulation was related to the CLOCK-BMAL1 (CLOCK-ARNTL) heterodimer, which would bind through an E-box enhancer to activate the transcription of the gene encoding vasopressin. However, the gene's importance in circadian rhythms was not fully realized until the knockout of the gene in mice showed complete loss of circadian rhythms in locomotion and other behaviors.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「ARNTL」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|