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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク BU-48 ： ウィキペディア英語版 BU-48 BU-48 is a drug that is used in scientific research. It is from the oripavine family, related to better-known drugs such as etorphine and buprenorphine. The parent compound from which BU-48 was derived (with N-methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group) is a powerful μ-opioid agonist 1000x more potent than morphine,〔Lewis JW, Bentley KW, Cowan A. Narcotic Analgesics and Antagonists. ''Annual Reviews in Pharmacology'' 1971;11:241-270.〕 but in contrast BU-48 has only weak analgesic effects and instead acts primarily as a δ-opioid agonist. Its main effects are to produce convulsions,〔Broom DC, Guo L, Coop A, Husbands S, Lewis JW, Woods JH, Traynor JR. BU48: A novel buprenorphine analogue that exhibits delta-opioid mediated convulsions but not delta-opioid-mediated antinociception in mice. ''Journal of Pharmacology and Experimental Therapeutics'' 2000 Sep; 294(3): 1195–1200. PMID 10945877〕 but it may also have antidepressant effects.〔Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? ''Japanese Journal of Pharmacology''. 2002 Sep;90(1):1-6. PMID 12396021〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「BU-48」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.