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Bemegride
Bemegride (also marketed as Megimide) is a central nervous system stimulant and antidote for barbiturate poisoning as its chemoreceptor agonism increases mean tidal volume, thereby increasing respiration and the concentration of O2 in blood although it may be theoretically used as a supportive measure in treating any depressant overdose. The drug's synthesis was invented in 1911.
As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose although emesis and aspiration are a concern during treatment.
== John Bodkin Adams case ==
Bemegride is notable in legal history as the drug suspected serial killer Dr John Bodkin Adams failed to prescribe correctly to his patient Gertrude Hullett. Hullett took an overdose of barbiturates on 19 July 1956 but Adams only gave her a single 10cc dose of bemegride three days later on the 22nd, despite having acquired 100cc for her treatment. Hullett died the next day on 23 July 1956. Adams was charged but never tried for her murder.〔Cullen, Pamela V., ''A Stranger in Blood: The Case Files on Dr John Bodkin Adams'', London, Elliott & Thompson, 2006, ISBN 1-904027-19-9〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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