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Benzamil
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Benzamil : ウィキペディア英語版
Benzamil

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Benzamil or benzyl amiloride is a potent blocker of the ENaC channel 〔cite journal | last = Chalfant | first = M.L.
| year = 1995
| title = Regulation of epithelial Na+ channels from M-1 cortical collecting duct cells
| journal= AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY
| volume=271
| pages=f861-f870
〕 and also a sodium-calcium exchange blocker.〔
〕 It is a potent analog of amiloride, and is marketed as the hydrochloride salt (benzamil hydrochloride). As amiloride, benzamil has been studied as a possible treatment for cystic fibrosis, although with disappointing results.
==Structure==
Benzamil is a benzyl group-containing analog of amiloride. Like amiloride, it is a guanidinium group-containing pyrazine derivative.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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