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Benzbromarone : ウィキペディア英語版 | Benzbromarone
Benzbromarone (INN) is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone. Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol, a xanthine oxidase inhibitor but not uricosuric, and probenecid, another uricosuric drug. ==Effect on cytochrome P450== Benzbromarone is a very potent inhibitor of CYP2C9.〔 Several analogues of the drug have been developed as CYP2C9 and CYP2C19 inhibitors for use in research.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Benzbromarone」の詳細全文を読む
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