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BinCARD
Bcl10-interacting CARD protein, also known as BinCARD, is a protein that in humans is encoded by the ''C9orf89'' gene on chromosome 9.〔UniProt: 〕 BinCARD is a member of the death-domain superfamily and contains a caspase recruitment domain (CARD). This protein regulates apoptosis and the immune response by inhibiting Bcl10, thus implicating it in diseases stemming from Bcl10 dysfunction.〔 == Structure ==
BinCARD, as a CARD-containing protein, is a member of the death-domain superfamily, which shares a six—helix bundle.〔 In humans, the protein has two alternatively spliced isoforms: BinCARD-1 and BinCARD-2. Both isoforms share identical sequences until residue 101, which include the CARD domain and exons 1 to 3. The longer isoform, BinCARD-1, has an extended exon 3, while the shorter BinCARD-2 has an extra transmembrane domain.〔 The conserved CARD domain has three cysteines in its native form: Cys7, Cys77, and Cys63, of which Cys7 and Cys77 form a disulfide bond and Cys63 becomes a cysteine sulfenic acid when oxidized.〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「BinCARD」の詳細全文を読む
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