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Bioenhancers or bioavailability enhancers is a new chapter in medical science first scientifically established in 1979 after the discovery of world's first bioenhancer Piperine. It is a pocket friendly drug technology which reduces the destruction, wastage and elimination of several orally administered drugs inside the body. Definition Bioenhancers are defined as substances that increase the bioavailability and bioefficacy of active substances with which they are combined without having any activity of their own at the dose used. Besides several classes of modern drugs like antibiotics, anti cancer drugs, cardiovascular drugs, anti inflammatory, central nervous drugs, etc, they also increase the bioavailability of vitamins and nutrients. Increased Bioavailabiity means increased levels of drug in the blood stream available for drug action. Increased Bioefficecy means the increased effectiveness of the drug due to increased bioavailability and also due to other mechanisms. Significance of Bioenhancers Due to an increased bioavailability, the dose and cost of active drug can be reduced,making the formulation cheaper and safer. Safer formulation also means better tolerated, having better compliance and therefore having lesser risk of developing drug resistance as in case of antibiotics.As it benefits the dose economy,it is particularly of great value to poor ill diseased segment of society.For example, by reducing the required dose of expensive toxic Rifampicin by 60 percent,it correspondingly reduces the cost and side effects of Rifampicin while treating the dreaded disease Tuberculosis. History Bioenhancers as a term and chapter did not exist in any scientific literature prior to 1979. The term bioavailability enhancers was first coined in 1979 at Indian Institute of Integrative medicine, Jammu, formerly RRL,Jammu, by Indian scientists (Dr. C. K. Atal proposed the hypothesis of increased bioavailability from a clue during research on traditional medicinal drugs and subsequently scientifically researched and scientifically established by him and his research team) . RRL Jammu then discovered and scientifically validated Piperine as world's first bioenhancer. Classification bioenhancers can be classified according to their source of origin,either plant based or animal based or else according to their site of action. Bioenhancers so far almost exclusively discovered in plants, increase the bioavailability of other substances in different ways: * Increase of absorption in the intestine * Inhibition of degradation in the intestine and the liver * Increase of permeability of pathogens * Inhibition of defense mechanisms of pathogens or tumor tissue (such as efflux of drugs) * Increasing binding possibilities on binding sites (such as DNA and proteins) of the pathogen * Improving overcoming of the blood-brain barrier Role of bioenhancers • 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Bioenhancer」の詳細全文を読む スポンサード リンク
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