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|Section2= |Section6= |Section7= }} Biotin, also known as vitamin H or coenzyme R,〔(【引用サイトリンク】 title=Biotin )〕 is a water-soluble B-vitamin (vitamin B7). It is composed of a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. The only human health condition for which there is strong evidence of biotin's potential benefit as a treatment is biotin deficiency.〔 ==General overview== Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. Biotin assists in various metabolic reactions involving the transfer of carbon dioxide. It may also be helpful in maintaining a steady blood sugar level.〔(Supplementinfo.org )〕 Biotin is often recommended as a dietary supplement for strengthening hair and nails, though scientific data supporting this outcome are weak. Nevertheless, biotin is found in many cosmetics and health products for the hair and skin.〔(【引用サイトリンク】title=Hair Growth With Biotin )〕〔(【引用サイトリンク】title=Biotin| )〕 Biotin deficiency is rare because, in general, intestinal bacteria produce biotin in excess of the body's daily requirements. For that reason, statutory agencies in many countries, for example the USA and Australia,〔(National Health and Medical Research Council: Nutrient Reference Values for Australia and New Zealand )〕 do not prescribe a recommended daily intake of biotin. However, a number of metabolic disorders exist in which an individual's metabolism of biotin is abnormal, such as deficiency in the holocarboxylase synthetase enzyme which covalently links biotin onto the carboxylase, where the biotin acts as a cofactor. High doses of biotin may play a role in stopping and reversing progression in progressive multiple sclerosis, as shown in a small pilot study of 23 patients in France. 91% of these patients were judged to have improved clinically. There was a 2 to 8 month lag in improvements. There are few treatment options for progressive MS. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Biotin」の詳細全文を読む スポンサード リンク
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