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Bivalirudin : ウィキペディア英語版
Bivalirudin

Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).
Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech ''Hirudo medicinalis'').
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin.〔 It inhibits both circulating and clot-bound thrombin,〔 while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life.〔 It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS).〔 It does not require a binding cofactor such as antithrombin and does not activate platelets.〔 These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials.〔〔〔 Patients receiving bivalirudin had fewer adverse events compared to patients that received heparin.
==Indications==

''US (United States) Indications'':〔
*Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).
*Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI).
*Bivalirudin is indicated for patients with, or at risk of HIT/HITTS undergoing PCI.
*Bivalirudin is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin
''EU (European) indications'':
*Percutaneous Coronary Intervention (PCI), including patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI.
*Bivalirudin is also indicated for the treatment of adult patients with unstable angina/non-ST segment elevation myocardial infarction (UA/NSTEMI) planned for urgent or early intervention.
*Bivalirudin should be administered with aspirin and clopidogrel.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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