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BDPC
BDPC (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent narcotic analgesic with a distinctive arylcyclohexylamine chemical structure. It was developed by Daniel Lednicer at Upjohn in the 1970s.〔 - 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use〕 Initial studies estimated that it was around 10,000 times the strength of morphine in animal models. However, later studies assigned a value of 504 times the potency of morphine for the more active ''trans''-isomer. To date, it is unknown if this drug has been used by humans, however, it was seized along with three kilograms of acetylfentanyl in an April 25, 2013 police action in Montreal, Canada. Despite taking precautions, at least two officers became intoxicated due to handling the drugs.
== Structure-activity relationships ==
Several related analogs such as the ''p''-methyl and ring-unsubstituted compounds have also been investigated.〔(''Report'' 1985, 21 pages, from Foersvarets Forskningsanstalt, Umea, Sweden. (Report in Swedish) )〕 BDPC is the lead compound in this series that attracted so much interest in it initially. A large number of analogs have been prepared, and the SAR is very well established. Lednicer constructed Dreiding models to show that the model of BDPC will give an exact overlay on a model of fentanyl.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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