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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Buprenorphine-3-glucuronide ： ウィキペディア英語版 Buprenorphine-3-glucuronide Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. It has affinity for the μ-opioid receptor (Ki = 4.9 (± 2.7) pM), δ-opioid receptor (Ki = 270 nM), and nociceptin receptor (Ki = 36 μM), but not for the κ-opioid receptor.〔 Whether B3G acts as an agonist or antagonist of each the former three sites has yet to be determined. In rats, at the doses assayed, B3G has been found to produce a small degree of antinociception, and similarly to buprenorphine in these assays, has not been found to produce sedation, reduce locomotion, or decrease respiratory rate.〔 Of all of the active metabolites of buprenorphine, B3G is thought to be the most similar to the parent drug.〔 Unlike norbuprenorphine, but similarly to buprenorphine (and norbuprenorphine-3-glucuronide), B3G is not a substrate for P-glycoprotein.〔 ==See also== * Morphine-3-glucuronide 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Buprenorphine-3-glucuronide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.