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Butamirate : ウィキペディア英語版
Butamirate

Butamirate (or brospamin) is a cough suppressant.
A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.
As a 2-(2-diethylaminoethoxy)ethyl ester it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)

File:Oxeladin.png|Oxeladin
File:Pentoxyverine skeletal.svg|Pentoxyverine

==Synthesis==

Prepd by the esterification of phenylethylacetyl chloride with diethylaminoethoxyethanol.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Butamirate」の詳細全文を読む



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