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C10orf76
C10orf76 or chromosome 10 open reading frame 76, also known as UPF0668, is a protein that in humans is encoded by the ''c10orf76'' gene.〔(【引用サイトリンク】url=http://www.ncbi.nlm.nih.gov/gene/79591 )〕 Its function is not currently known, but experimental evidence has suggested that it may be involved in transcriptional regulation.〔 The protein contains a conserved proline-rich motif,〔〔(【引用サイトリンク】url=http://blast.ncbi.nlm.nih.gov/Blast.cgi )〕 suggesting that it may participate in protein-protein interactions via an SH3-binding domain,〔 although no such interactions have been experimentally verified. The well-conserved gene appears to have emerged in Fungi approximately 1.2 billion years ago.〔〔(【引用サイトリンク】url=http://www.timetree.org/index.php?taxon_a=homo+sapiens&taxon_b=aspergillus+oryzae&submit=Search )〕 The locus is alternatively spliced and predicted to yield five protein variants, three of which contain a protein domain of unknown function, DUF1741.〔〔
== Function ==
The function of c10orf76 is not yet known. It has been found to contain a potential SH3-binding domain,〔 which is known to participate in protein-protein binding interactions; however, no protein interactions have been experimentally verified with c10orf76. A 2007 gene expression study found c10orf76 expression to vary inversely with the expression of several other genes, including NFYB, CCR5, and NSBP1, suggesting that the protein may function as a transcriptional regulator.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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