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C14orf102
Chromosome 14 open reading frame 102 (accession: AK294958; alias: C14orf102, FLJ14051, FLJ10008, FLJ52106)〔(C14orf102 Gene - GeneCards | CN102 Protein | CN102 Antibody )〕 is a 3810bp protein-encoding gene that is highly conserved among its non-distant orthologs. It contains 20 introns and 8 different RNAs - 7 splice variants and 1 unspliced form - and is located on the reverse strand of chromosome 14 (14q32.11).〔(AceView: Gene:C14orf102, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView )〕 The protein encoded by this gene (accession: BAG58032) belongs to the UPF0614 family of Up-frameshift proteins and has a molecular weight of 132.417 kDa and isoelectric point of 7.88. It is expected to have a protein binding function and localization in the cytoplasm.〔(C14orf102 (human) )〕
==Expression==
According to EST profiles, C14orf102 is most highly expressed in the esophagus (98 TPM) and trachea (76), and is further expressed in multiple different tissues.〔(EST Profile - Hs.528131 )〕 However, the AceView summary suggests that this gene is expressed most highly in the brain, followed by decreased expression in 81 separate tissues. This is inferred in the reconstruction of the mRNA sequence, as well as exon sequencing, in that the majority of cDNA clones used for each procedure were found in the brain. This is consistent with GenBank record, which indicates that the cDNA clone was also isolated from brain tissue. The general expression of the gene is high, being 1.8 times that of average gene expression.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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