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C7orf30
C7ORF30 (chromosome 7 open reading frame 30) is a gene on chromosome 7 in humans that encodes the protein LOC_115416.〔(【引用サイトリンク】 url =http://www.ncbi.nlm.nih.gov/protein/19923977 )〕 This protein localizes to mitochondria and is probably involved in mitochondrial translation or the biogenesis of the large subunit of the mitochondrial ribosome.
== Protein ==
LOC_115416 is a member of the DUF143 family (= domain of unknown function (143 ), ) which is highly conserved in both prokaryotes and eukaryotes but not archaea. Examples of mammalian conservation are given below using the ALIGN tool from the San Diego Supercomputer Center Biology Workbench. Percentages indicate the identity shared by the human protein and the respective mammalian protein. Accession numbers are from the NCBI database.
There are no known or predicted paralogs in ''Homo sapiens''. That is, C7Orf30 is a single-copy gene.
The domain is from position 93 to 194 on the human protein and comprises 43.2% of the sequence. This conserved domain is also present in the plant gene iojap, a pattern-striping gene in maize.〔(【引用サイトリンク】url =http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004394 )〕 However, since its function has been solved at least in bacteria, it is no longer a "domain of unknown function".
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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