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C957T
The C957T gene polymorphism is a synonymous mutation located within the 957th base pair of the DRD2 gene. This base pair is located in exon 7. Most synonymous mutations are silent. However, the C957T mutation is an exception to this rule. While the 957C allele codes for the same polypeptide as the 957T allele, the conformation of 957T messenger RNA differs from the conformation of 957C messenger RNA. 957T messenger RNA is less stable and more prone to degradation. As a result, dopamine D2 receptor expression is decreased among individuals who carry the 957T allele compared to individuals who carry the 957C allele.〔(Molecular Psychiatry - C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo )〕
==Behaviours associated with the C/C genotype of the C957T polymorphism==
* schizophrenia
* diminished working memory ability
* altered response to nicotine 〔(C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency - Springer )〕
* reward related impulsivity 〔(Interaction Between DRD2 C957T Polymorphism and An Acute Psychosocial Stressor on Reward-Related Behavioral Impulsivity - Springer )〕
* sucrose addiction 〔(Dopamine D2 Receptor Genotype (C957T) and Habitual Consumption of Sugars in a Free-Living Population of Men and Women )〕
* altered susceptibility to iatrogenic tardive dyskinesia 〔(Cambridge Journals Online - Abstract )〕
* altered fear conditioning 〔(The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming - Huertas - 2009 - Genes, Brain and Behavior - Wiley Online Library )〕
* dissocial personality disorder 〔(DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study )〕
* posttraumatic stress disorder 〔(The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans - Voisey - 2008 - Depression and Anxiety - Wiley Online Library )〕
Given that the C/C genotype has been associated with dissocial personality disorder one may infer that this genotype may also be associated with all four DSM-IV defined cluster B personality disorders. This hypothesis, however, has not been tested.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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