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Computer Atlas of Surface Topology of Proteins
(CASTp) ''or'' Computer Atlas of Surface Topology of Proteins, is a tool in Bioinformatics which is an online resource for identifying some of the geometric properties of protein like locating, delineating and measuring concave surface regions on 3D structures of proteins obtained from PDB also to study surface features, functional regions and active site of proteins. there is also measurement of the number of mouth openings(of pocket), area of the openings(of pocket), circumference of mouth opening(of pocket), in both solvent accessible(SA) and Molecular surface(MS) of each pocket. The pocket which does not have any opening to the outside is called cavity(void), it doesn't have any opening for the solvent probe. This server is maintained by University of Illinois at Chicago UIC.〔(Search CASTp database )〕
== Algorithm ==
The measurement includes the area and volume of pocket or void as well as measurement of numbers of mouth opening of a particular pocket ID by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly's surface), all calculated analytically.〔(CASTp: Computed Atlas of Surface Topography of proteins )〕 The core algorithm helps in finding the pocket or cavity with capability of housing a solvent with a diameter of 1.4 Å. Predicting a binding site in a protein is a fundamental step of docking or drug designing. As this tool helps in finding cavity or pockets in the structure it is used for identifying active sites where drugs can bind.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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