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・ CBERS-1
・ CBERS-2
・ CBERS-2B
・ CBERS-3
・ CBERS-4
・ CBET
・ CBET-DT
・ CBEW-FM
・ Cbeyond
・ CBF
・ CBF Elda
・ CBF ranking
・ CBF-FM
・ CBF-FM-10
・ CBF-FM-8
CBFA2T2
・ CBFA2T3
・ CBFB
・ CBFC
・ CBFT-DT
・ CBFX-FM
・ CBG
・ CBG (AM)
・ CBGA
・ CBGA-FM
・ CBGB
・ CBGB (film)
・ CBGB Forever
・ CBH
・ CBH Bank


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CBFA2T2 : ウィキペディア英語版
CBFA2T2

Protein CBFA2T2 is a protein that in humans is encoded by the ''CBFA2T2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139 )
== Function ==

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「CBFA2T2」の詳細全文を読む



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