翻訳と辞書 Words near each other ・ CBKR ・ CBKST ・ CBKT-DT ・ CBL ・ CBL & Associates Properties ・ CBL (gene) ・ CBL Index ・ Cbl TKB domain ・ CBL-FM ・ CBLA-FM ・ CBLA-FM-2 ・ CBLB ・ CBLB (gene) ・ CBLC ・ CBLFT-DT ・ CBLL1 ・ CBLN ・ CBLT-DT ・ CBM ・ CBM (charity) ・ CBM Bethel Hospital ・ CBM College of Arts and Science ・ CBM TV ・ CBM-CFS3 ・ CBM-FM ・ CBME ・ CBME-FM ・ Cbms ・ CBMT-DT ・ CBN Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク CBLL1 ： ウィキペディア英語版 CBLL1 The E3 ubiquitin-protein ligase Hakai (HAKAI) also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1) is an enzyme that in humans is encoded by the CBLL1 gene. This gene encodes an E3 ubiquitin ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. == Function == Hakai functions as a RING finger domain-containing E3 ubiquitin ligase for E-cadherin. Hakai mediates E-cadherin ubiquitination and its degradation by proteasomes. "Hakai" means "destruction" in Japanese. Proteosomal degradation of E-cadherin can be regulated by phosphorylation. The Hakai binding site is a part of the E-cadherin cytoplasmic domain that contains several tyrosines. Tyrosine kinases such as Src and Met can phosphorylate E-cadherin and enhance Hakai binding to E-cadherin. Two lysines of the E-cadherin cytoplasmic domain have been shown to be sites for ubiquitination. Hakai also interacts with polypyrimidine tract-binding protein-associated splicing factor. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CBLL1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.