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CCDC113
Coiled-coil domain-containing protein 113 also known as HSPC065, GC16Pof6842 and GC16P044152, is a protein that in humans is encoded by the ''CCDC113'' gene. The human CCDC113 gene is located on chromosome 16q21 and encodes 5,304 base pairs of mRNA and 377 amino acids.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29070 )〕
==Gene==
''CCDC113'' is located on chromosome 16q21 and encodes two distinct isoforms with isoform 2 containing one less alternate in-frame exon compared to the full length protein, isoform 1. Isoform 1 is composed of 5304 base pairs of mRNA which form the 9 exons that make up the coding sequence.〔
''CCDC113'', located between nucleotides 58283840 and 58317740 on chromosome 16, is surrounded between antisense genes ''PRSS54'' and ''CSNK2A2'' and downstream from ''GINS3'' and ''NDRG4'' on the sense strand. ''PRSS54'' is a trypsin-like serine protease which codes for the inactive serine protease 54 precursor.〔(【引用サイトリンク】url=http://www.ncbi.nlm.nih.gov/protein/NP_001073961.1 )〕 ''CSNK2A2'' the casein kinase 2, alpha prime polypeptide contains a protein kinase domain and a catalytic domain.〔(【引用サイトリンク】Homo sapiens (human) )">url=http://www.ncbi.nlm.nih.gov/gene/1459 )〕 ''GINS3'' is essential for the initiation of DNA replication and replisome progression in eukaryotes.〔(【引用サイトリンク】url=http://www.ncbi.nlm.nih.gov/gene/64785 )〕 ''NDRG4'' a member of the ''N-myc'' downregulated gene family belonging to the alpha/beta hydrolase superfamily which encodes a cytoplasmic protein responsible for cell cycle progression and survival in primary astrocytes and may be involved in regulation of mitogenic signaling in vascular smooth muscle cells.〔(【引用サイトリンク】url=http://www.ncbi.nlm.nih.gov/gene/65009 )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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