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CCL25
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CCL25 : ウィキペディア英語版
CCL25

Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (Thymus-Expressed Chemokine). CCL25 is believed to play a role in the development of T-cells.〔Vacari et al., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity, 1997, 7:291-301.〕 It is chemotactic for thymocytes, macrophages, and dendritic cells. CCL25 elicits its effects by binding to the chemokine receptor CCR9.〔Zaballos et al., Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol., 1999, 162:5671-5675.〕〔Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.〕 Human CCL25 is produced as a protein precursor containing 151 amino acids. The gene for CCL25 (''scya25'') is located on human chromosome 19.〔Nomiyama et al., The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2. Genomics, 1998, 51:311-312.〕
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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