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C-C chemokine receptor type 7
C-C chemokine receptor type 7 is a protein that in humans is encoded by the ''CCR7'' gene. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21).〔F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004〕
CCR7 has also recently been designated CD197 (cluster of differentiation 197).
== Function ==
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lymphoid organs, such as lymph nodes, as well as stimulate dendritic cell maturation.
Activation of Dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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